Related Experiment Video
Updated: Aug 13, 2026

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
Published on: September 19, 2016
Ethnic differences in selective neonatal BCG immunisation: white British children miss out
R Srinivasan1, L Menon, P Stevens
1Department of Child Health, Llandough Hospital, Cardiff CF64 2XX, UK. ramsriniv@doctors.org.uk
Insights
BCG vaccination rates for at-risk infants in Cardiff were 76% overall. White British infants had significantly lower BCG uptake compared to Asian and Black African infants, highlighting a need for improved awareness.
Area of Science:
- Public Health
- Epidemiology
- Immunization Practices
Background:
- Tuberculosis (TB) is a growing concern in Western Europe.
- Neonatal BCG vaccination is recommended for high-risk infants in the UK.
- BCG vaccination offers 75% protection against TB.
Purpose of the Study:
- To evaluate BCG vaccination rates among at-risk infants in Cardiff and the Vale of Glamorgan.
- To identify disparities in BCG uptake across different ethnic groups.
Main Methods:
- Identified a cohort of TB-risk infants using a maternity activity database.
- Manually reviewed immunization records to determine BCG vaccination rates.
- Analyzed vaccination rates by ethnic group.
Main Results:
- Out of 5308 infants, 514 (9.6%) were identified as at risk for TB.
- Overall, 391 (76%) at-risk infants received BCG vaccination.
- BCG vaccination rates were 36.5% for white British infants versus 83.6% for Asian and 82% for Black African infants.
Conclusions:
- The overall BCG vaccination rate among at-risk infants in Cardiff was 76%.
- White British infants showed a notably lower BCG vaccination rate compared to other ethnic groups.
- Increased health professional awareness is crucial for improving BCG coverage in diverse populations.
Background:
Tuberculosis (TB) is a re-emerging problem, especially in the larger cities of Western Europe. Selective neonatal BCG vaccination is recommended for infants at risk of TB in the UK. Neonatal BCG is safe and effective, with an overall protective value of 75%. This study aimed to assess BCG rates among at risk infants in Cardiff and the Vale of Glamorgan, South Wales in the year 2003.
Methods:
A cohort of infants at risk for TB was identified from demographic data stored on a computerised maternity activity database. A manual search of immunisation records determined overall rates and the rates for infants belonging to various ethnic groups.
Results:
Of 5308 infants born in 2003, 514 (9.6%) were at risk of TB; 423 (82.2%) of these infants were referred postnatally for BCG vaccination and 391 received it. Twenty six of the 41 at risk white British infants missed having a BCG vaccination compared with 47 of 288 Asian infants and seven of 39 black African babies. The rate of BCG vaccination among white British infants was 36.5% compared with 83.6% for Asian infants from the Indian subcontinent (chi(2) = 7.25, p<0.01) and 82% for black African infants (chi(2) = 4.48, p<0.05).
Conclusions:
The overall BCG rate among at risk infants in Cardiff was 76% during the study period. The vaccination rate was poor among white British infants compared with other ethnic groups. Enhanced awareness of health professionals to recognise the need for vaccinating certain white children at risk of TB is essential to improve BCG coverage in an increasingly multiethnic population.
Related Concept Videos
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Development of Human Microbiota
Transcytosis of IgG
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Probability Laws
Development of the Oral Microbiota
Vaccinations

