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Updated: Oct 8, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
AML with unusual chromosomal changes. Translocation (15;21) and 5q- in the presence of two normal chromosomes 5
J L Carrasco Juan1, A Otero Gómez, J L Garcia Miranda
1Cytogenetics Service, Faculty of Medicine, University of La Laguna, Canary Islands, Spain.
Abstract:
We performed serial cytogenetic studies of the bone marrow (BM) of a patient with acute myeloblastic leukemia (AML) and noted abnormal karyotypes 47,XY,+del(5)(q12q34),t(15;21)(q21;q22)/47,XY,+del(5)(q12q34 ) during the second relapse. Although a case of this t(15;21) was recently observed in a female patient with acute nonlymphocytic leukemia (ANLL) of subtype M4 of the French-American-British (FAB) classification, the present article constitutes the first report of its occurrence in association with ANLL of subtype M1-M2. Furthermore, the presence of the 5q- accompanied by two chromosomes 5 of normal appearance is very rare and of great interest.
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