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Dynamic Assessments of Coronary Flow Reserve after Myocardial Ischemia Reperfusion in Mice
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TNF-alpha contributes to endothelial dysfunction in ischemia/reperfusion injury

Cuihua Zhang1, Xiangbin Xu, Barry J Potter

  • 1Department of Anesthesiology, LSU Health Sciences Center, New Orleans, LA 70112, USA. czhang@lsuhsc.edu

Arteriosclerosis, Thrombosis, and Vascular Biology
|December 31, 2005
PubMed
Summary

Myocardial ischemia/reperfusion injury causes coronary endothelial dysfunction by increasing tumor necrosis factor-alpha (TNF-alpha). This leads to xanthine oxidase activation and superoxide production, impairing blood vessel function.

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