Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypoxia-induced changes in neuronal network properties.

Fernando Peña1, Jan-Marino Ramirez

  • 1Departamento de Farmacobiología, Cinvestav-Coapa, México. jfpena@cinvestav.mx

Molecular Neurobiology
|December 31, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Astrocyte activation in the ventrolateral medulla modulates breathing and arousal states.

Nature communications·2026
Same author

Opioid-induced respiratory depression: an underappreciated role of the peripheral nervous system.

Journal of neurophysiology·2026
Same author

Mecp2 deficiency induces dysphagia in a preclinical model of Rett syndrome.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Tachykinergic signaling mediated by NK1 receptors in the respiratory parafacial region drives respiratory output and contributes to the chemoreflex response to CO<sub>2</sub>.

Pflugers Archiv : European journal of physiology·2026
Same author

Effects of Isoflurane Inhibition of Mitochondrial Complex I on Calcium Removal in Mouse Neuronal Cultures.

Anesthesiology·2025
Same author

Fentanyl blockade of K<sup>+</sup> channels contributes to wooden chest syndrome.

The Journal of physiology·2025
Same journal

Exerkine-Mediated Regulation of the NLRP3 Inflammasome in Neuroprotection: Mechanistic Insights and the Role of Exercise.

Molecular neurobiology·2026
Same journal

miR-6836-5p Drives Astrocyte Pro-survival Signaling Through DLG2-Hippo-YAP Pathway Under AQP4-IgG + ve NMOSD Stress.

Molecular neurobiology·2026
Same journal

Nrf2 Activators in Parkinson's Disease: Modulating Mitophagy and Regulating Cuproptosis.

Molecular neurobiology·2026
Same journal

The Molecular Machinery of Synaptic Plasticity and Its Potential Role in the Aetiology of Schizophrenia.

Molecular neurobiology·2026
Same journal

Hypothalamus Amyloid Levels Are Associated with Early Sex-Dependent Alterations in Peripheral Energy Homeostasis in TgF344-AD Rats.

Molecular neurobiology·2026
Same journal

A Dose-Response Study on Human FGF21 to Inhibit Necrosis, Spectrin Breakdown, and to Increase Intracellular Cold Shock Proteins in Cultured Cortical Neurons Subjected to Oxygen-Glucose Deprivation Injury.

Molecular neurobiology·2026
See all related articles

The mammalian central nervous system

Area of Science:

  • Neuroscience
  • Physiology
  • Cellular Biology

Background:

  • Neurons have high energy demands and are sensitive to oxygen levels.
  • Hypoxia triggers complex survival responses in mammals.
  • The nervous system's response to hypoxia is multifaceted.

Purpose of the Study:

  • To review the nervous system's response to hypoxia.
  • To integrate cellular and network-level events in understanding hypoxia.
  • To explore the functional and organismal context of hypoxic responses.

Main Methods:

  • Review of existing literature on nervous system hypoxia.
  • Analysis of molecular, cellular, synaptic, neuronal, and network-level changes.
  • Integration of diverse hypoxic response factors.

Related Experiment Videos

Main Results:

  • Hypoxia elicits biphasic breathing responses and behavioral changes.
  • Hypoxic response is influenced by environmental and organismal factors.
  • Synaptic transmission is generally depressed via presynaptic mechanisms.
  • Intrinsic neuronal properties are altered by ion channel modulation.

Conclusions:

  • Nervous system response to hypoxia involves widespread network reconfigurations.
  • Understanding cellular events requires considering network and organismal context.
  • Hypoxia can induce pathology or serve as therapy, necessitating comprehensive study.