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Updated: Aug 13, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
Published on: September 16, 2017
[Are there differences among anti-TNFα biological drugs?]
1Dipartimento di Clinica e Terapia Medica Applicata, Cattedra di Reumatologia, Università degli Studi La Sapienza, Roma, Italia. guido.valesini@uniroma1.it
Objective:
To provide an analysis and a guide tool in using TNFα-antagonists in the current clinical practice.
Methods:
Review of the literature on the differences among the three TNFα-antagonists in terms of molecular structure, mechanism of action, pharmacokinetics, effects on the immune and neuroendocrine systems, and therapeutic indications.
Results And Conclusions:
Unfortunately, results of direct comparison studies are lacking. One could obviate this problem by performing statistical-mathematical extrapolations, but there are very few and very small-sized published experimental evidences.
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