Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Genetic alterations underlying colorectal tumorigenesis.

¹Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

Cancer Surveys

|January 1, 1992

Summary

Colorectal tumors develop from multiple genetic changes in oncogenes and tumor suppressor genes. The adenomatous polyposis coli (APC) gene mutation predisposes individuals to colorectal tumors, aiding cancer research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

MSX2 is an oncogenic downstream target of activated WNT signaling in ovarian endometrioid adenocarcinoma.

Oncogene·2011

Same author

The transcription factor snail represses Crumbs3 expression and disrupts apico-basal polarity complexes.

Oncogene·2008

Same author

Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon.

The American journal of pathology·2001

Same author

Diverse mechanisms of beta-catenin deregulation in ovarian endometrioid adenocarcinomas.

Cancer research·2001

Same author

Organ-specific molecular classification of primary lung, colon, and ovarian adenocarcinomas using gene expression profiles.

The American journal of pathology·2001

Same author

Constitutive activation of the Wnt signaling pathway by CTNNB1 (beta-catenin) mutations in a subset of human lung adenocarcinoma.

Genes, chromosomes & cancer·2001

Area of Science:

Oncology
Genetics
Molecular Biology

Background:

Colorectal tumors are a model for studying genetic alterations in neoplasm development.
Tumorigenesis is linked to accumulated genetic alterations in oncogenes and tumor suppressor genes.
The adenomatous polyposis coli (APC) gene, when mutated, predisposes to colorectal tumors.

Purpose of the Study:

To investigate the genetic alterations in colorectal tumor development.
To propose a genetic model for colorectal cancer development based on inherited and somatic mutations.
To identify key genes and their roles in tumor initiation and progression.

Main Methods:

Analysis of somatic and germline mutations in colorectal tumors.
Identification of the adenomatous polyposis coli (APC) gene.
Development of a genetic model for colorectal cancer.

Main Results:

Colorectal tumors arise from multiple genetic alterations.
APC gene mutations are linked to hereditary colorectal tumors.
A genetic model for colorectal cancer progression has been proposed.

Conclusions:

The proposed genetic model provides a framework for studying colorectal cancer.
Further research is needed to understand gene function, mutation mechanisms, and their contribution to tumor stages.
Insights into human cancer pathogenesis are achievable through studying colorectal tumorigenesis.

Related Experiment Videos