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Updated: Aug 13, 2026

A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy
Published on: January 30, 2019
Determination of ionization constant (pKa) and octanol-water partition coefficient (Log P) of cyclopiazonic acid
1U.S. Department of Agriculture, Agricultural Research Service, National Peanut Research Laboratory, P.O. Box 509, Dawson, GA 39842, USA. vsobolev@nprl.usda.gov
Abstract:
The ionization constant (pKa) and the octanol-water partition coefficient (log P) of the important mycotoxin cyclopiazonic acid (CPA) were determined by means of potentiometric titration, and the lipophilicity profile (log D) was calculated. Under the experimental conditions, pKa of CPA = 2.97 +/- 0.09, log P = 3.83 +/- 0.10, and log D at pH 7.4 = -0.58.
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