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Prevalence of hepatitis C virus infection in north-eastern Brazil: a population-based study

Maria Alice S Zarife1, Luciano K Silva, Maria Betânia S Silva

  • 1Laboratório de Patologia e Biologia Molecular, Centro de Pesquisas Gonçalo Moniz da FIOCRUZ, R. Waldemar Falcão 121, Brotas, 40295-001 Salvador, Bahia, Brazil.

Transactions of the Royal Society of Tropical Medicine and Hygiene
|January 3, 2006
PubMed

In general, the prevalence and genotype distribution of hepatitis C virus (HCV) are estimated based on the ambulatory clinic or hospital population. In the present work, a population-based study was conducted to estimate the prevalence of HCV infection in Salvador, Brazil. A total of 1308 serum samples were collected from 30 "sentinel areas", and the prevalence of HCV infection was determined by ELISA and confirmed by recombinant immunoblot assay and RT-PCR. The overall prevalence of HCV infection was 1.5% (20/1308). Prevalence was greater among those aged 35 years or older and those with more education. Genotype 3 was the most common (53.3%), followed by genotypes 1 (40%) and 2 (6.7%). These observations are different from those found in a prior survey of hospital and ambulatory patients in Salvador, who were most frequently infected with genotype 1, followed by genotypes 3 and 2, respectively.

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