Cyclodextrin-grafted polysaccharides as supramolecular carrier systems for naproxen

Area of Science:

• Polymer Chemistry
• Supramolecular Chemistry
• Pharmacology

Background:

• Developing effective drug delivery systems is crucial for enhancing therapeutic outcomes.
• Polysaccharides like dextran, mannan, and carboxymethylcellulose offer biocompatible scaffolds for drug modification.
• Beta-cyclodextrin is known for its ability to form inclusion complexes with various drugs.

Purpose of the Study:

• To synthesize novel beta-cyclodextrin-grafted polymers using dextran, mannan, and carboxymethylcellulose.
• To evaluate these modified polymers as supramolecular carriers for the anti-inflammatory drug, naproxen.
• To assess the in vivo anti-inflammatory efficacy of naproxen when delivered via these novel carriers.

Main Methods:

• Periodate oxidation was used to activate dextran, mannan, and carboxymethylcellulose.
• Reductive alkylation with beta-cyclodextrin moieties in the presence of sodium borohydride was employed for grafting.
• The synthesized polymers were utilized as supramolecular carriers for naproxen, and their in vivo anti-inflammatory effects were evaluated.

Main Results:

• Successful grafting of beta-cyclodextrin moieties onto activated polysaccharide backbones was achieved.
• The resulting beta-cyclodextrin-grafted polymers demonstrated utility as supramolecular carriers for naproxen.
• Significant improvement in the in vivo anti-inflammatory properties of naproxen was observed when delivered by these carriers.

Conclusions:

• Beta-cyclodextrin-grafted polysaccharides represent a promising approach for developing advanced drug delivery systems.
• These supramolecular carriers can effectively enhance the in vivo anti-inflammatory activity of naproxen.
• The study highlights the potential of tailored polymer design for improving drug efficacy and therapeutic performance.