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Factors involved in baseline hyperhomocysteinemia in renal transplantation

J M Díaz1, Z Sainz, I Gich

  • 1Renal Transplantation Unit, Nephrology Department, Fundació Puigvert, Barcelona, Spain. jdiaz@fundacio-puigvert.es

Transplantation Proceedings
|January 3, 2006
PubMed

Insights

Elevated homocysteine (hyperHcy) is a cardiovascular risk. In renal transplant patients, hyperHcy prevalence was 61.2%, linked to lower folate/B12 and poorer kidney function.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Clinical Chemistry

Background:

  • Hyperhomocysteinemia (hyperHcy) is a recognized risk factor for cardiovascular disease.
  • Renal transplant recipients are a population susceptible to cardiovascular complications.

Purpose of the Study:

  • To determine the prevalence of hyperHcy in renal transplant patients.
  • To identify demographic, clinical, and analytical factors associated with hyperHcy in this cohort.

Main Methods:

  • Cross-sectional study design.
  • Categorization of patients into hyperHcy and normal-homocysteinemia groups.
  • Multivariate analysis to identify independent predictors of Hcy levels.

Main Results:

  • The prevalence of hyperHcy was 61.2% with a mean Hcy level of 17.3 micromol/L.
  • HyperHcy was associated with male gender, lower intraerythrocyte folate and vitamin B12, higher fibrinogen, and reduced renal function.
  • Creatinine clearance, folate, vitamin B12, and fibrinogen were independently associated with Hcy levels.

Conclusions:

  • Hyperhomocysteinemia is highly prevalent in renal transplant patients.
  • Specific clinical and biochemical factors are significantly associated with elevated homocysteine levels in this population.
  • These findings highlight potential targets for intervention to mitigate cardiovascular risk in renal transplant recipients.

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