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Related Experiment Videos

Bioartificial liver: current status.

G Pless1, I M Sauer

  • 1Charité, Campus Virchow, General, Visceral and Transplantation Surgery, Berlin, Germany. gesine.pless@charite.de

Transplantation Proceedings
|January 3, 2006
PubMed
Summary
This summary is machine-generated.

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Liver failure necessitates advanced treatments. Artificial and bioartificial liver support systems offer alternatives to transplantation by aiding detoxification, synthesis, and regulation, addressing toxin accumulation in patients.

Area of Science:

  • Hepatology
  • Biomedical Engineering
  • Critical Care Medicine

Background:

  • Liver failure is a life-threatening condition with a critical shortage of donor organs.
  • Extracorporeal liver support aims to replace or assist failing liver functions: detoxification, synthesis, and regulation.
  • Toxin accumulation, due to impaired liver clearance, is a key clinical issue in liver failure.

Purpose of the Study:

  • To provide an overview of artificial and bioartificial liver support devices.
  • To discuss the current state and challenges of extracorporeal liver support systems.
  • To highlight the potential of these systems as alternatives to liver transplantation.

Main Methods:

  • Review of artificial liver support devices focusing on detoxification (e.g., MARS, SPAD, Prometheus).

Related Experiment Videos

  • Review of bioartificial liver support systems utilizing liver cells (e.g., ELAD, HepatAssist, MELS, AMC-BAL).
  • Discussion of the principles behind toxin removal and the challenges in replicating synthesis and regulation.

    • Main Results:

    • Several artificial detoxification devices (MARS, SPAD, Prometheus) are under clinical evaluation.
    • Various bioartificial liver support systems (ELAD, HepatAssist, MELS, AMC-BAL) are being developed.
    • These systems aim to remove toxins like bilirubin, bile acids, and cytokines.

    Conclusions:

    • Artificial and bioartificial liver support systems show promise in managing liver failure.
    • Significant obstacles remain in fully replicating the liver's complex functions, particularly synthesis and regulation.
    • Further development is crucial for these extracorporeal methods to become viable alternatives to liver transplantation.