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Updated: Aug 13, 2026

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors
13:34

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors

Published on: March 17, 2014

Plasmacytoid dendritic cells: in vivo regulators of alloimmune reactivity?

M Abe1, B L Colvin, A W Thomson

  • 1Thomas E Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh Medical Center, PA 15213, USA.

Transplantation Proceedings
|January 3, 2006
PubMed

Dendritic cells (DC) exhibit remarkable plasticity in terms of their ability to induce and regulate innate and adaptive immune responses. Human and mouse interferon alpha-producing plasmacytoid (p) DC have been found to regulate allogeneic T cell responses in vitro. Evidence is emerging that pDC may also regulate immune reactivity in vivo, including the responses that underlie graft-versus-host disease and organ transplant rejection. These cells may also offer potential for therapy of adverse immune responses and the promotion of tolerance induction.

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