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Long-term outcome of cadaveric pediatric en bloc transplantation--a 15-year experience

G P Smyth1, M P Eng, R P Power

  • 1Department of Urology and Transplantation, Beaumont Hospital, Dublin, Ireland.

Transplantation Proceedings
|January 3, 2006
PubMed

Insights

Pediatric en bloc kidney transplantation using infant organs in adults offers a viable solution to expand organ availability. This technique demonstrates excellent long-term allograft function and survival in selected adult recipients.

Area of Science:

  • Nephrology
  • Transplantation Surgery
  • Pediatric Surgery

Background:

  • Limited kidney donor pool necessitates innovative strategies.
  • Pediatric en bloc kidney transplantation is an established method to increase organ availability for adult recipients.

Purpose of the Study:

  • To evaluate the long-term outcomes of pediatric en bloc kidney transplantation in adult recipients.
  • To assess graft function, survival, and potential complications such as hyperfiltration injury.

Main Methods:

  • Retrospective review of 12 adult patients who received en bloc kidney transplants from donors younger than 4 years.
  • Analysis of graft function, patient survival, and complications over a 15-year period.

Main Results:

  • All 12 transplants functioned immediately with no instances of graft thrombosis.
  • Two patients died with functioning grafts at 10 and 12 years post-transplant.
  • The remaining 10 recipients showed excellent graft function with a mean follow-up of 73.8 months (range 10-169 months) and no hyperfiltration injury.

Conclusions:

  • Pediatric en bloc kidney transplantation is a safe and effective procedure for selected adult recipients.
  • This technique provides excellent long-term allograft function and survival, addressing donor organ scarcity.

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