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Updated: Aug 12, 2026
08:52
Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
Published on: May 27, 2011
Gancyclovir prophylaxis in high risk patients
1Department of Pharmacy, Barakaldo, Spain. ainara.campino@terra.es
Transplantation Proceedings
|January 3, 2006
Summary
Kidney transplant recipients who are CMV-seronegative but receive a CMV-seropositive kidney face a higher risk of cytomegalovirus (CMV) disease, even with ganciclovir treatment. This risk is elevated compared to CMV-seropositive recipients receiving a CMV-seropositive kidney without prophylaxis.
Area of Science:
- Nephrology
- Transplant Immunology
- Infectious Diseases
Background:
- Cytomegalovirus (CMV) disease is a significant post-transplant complication.
- Donor and recipient cytomegalovirus (CMV) serostatus impacts disease risk.
- Optimizing prophylaxis strategies is crucial for patient outcomes.
Purpose of the Study:
- To compare the incidence of cytomegalovirus (CMV) disease in CMV-seronegative recipients of CMV-seropositive kidneys (D+/R-) versus CMV-seropositive recipients of CMV-seropositive kidneys (D+/R+).
Main Methods:
- Retrospective analysis of 42 kidney transplant recipients.
- Categorization based on donor (D) and recipient (R) CMV serostatus: D+/R- and D+/R+.
- Analysis of immunosuppression types (cyclosporine, tacrolimus) and ganciclovir prophylaxis use.
Main Results:
- Overall CMV disease incidence was 23.8% (10/42 patients) within one year post-transplant.
- CMV disease occurred in two D+/R- patients not receiving ganciclovir prophylaxis.
- Higher CMV disease incidence was observed in patients on cyclosporine (41.7%) compared to tacrolimus (17.9%).
- CMV disease incidence was higher in D+/R- patients receiving ganciclovir prophylaxis than in D+/R+ patients without prophylaxis.
Conclusions:
- CMV-seronegative recipients of CMV-seropositive kidneys (D+/R-) have an increased risk of CMV disease.
- Ganciclovir prophylaxis may not fully mitigate CMV disease risk in D+/R- patients.
- Immunosuppression regimens, particularly cyclosporine, may influence CMV disease incidence.
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