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Evaluation of liver damage after application of TVE in the rat model
G Darilmaz1, S Topaloglu, E Topaloglu
1First Department of Surgery, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Introduction:
The aim of this study was to investigate the effects of total vascular exclusion (TVE) on the liver during the early period of reperfusion.
Materials And Methods:
Forty Wistar-Albino rats were divided into four groups. Portal pedicle clamping (groups 1 and 2) or TVE (groups 3 and 4) were applied for 10 minutes. Samples were collected at the time of clamp release (groups 1 and 3) and at 30 minutes of reperfusion (groups 2 and 4). We examined oxidative injury to and histopathology of the liver.
Results:
Oxidative stress was more prominent with TVE application. Significant alterations were shown in hepatic superoxide dismutase, catalase, glutathione, and glutathione S-transferase levels. The levels of malondialdehyde and myeloperoxidase were not altered significantly.
Conclusion:
Inflow-outflow occlusion of the liver causes more oxidative stress compared with inflow occlusion.
