Related Experiment Video
Updated: Aug 13, 2026

Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice
Published on: March 15, 2024
Predictors of drug use among South African adolescents
Judith S Brook1, Neo K Morojele, Kerstin Pahl
1Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA. judith.brook@med.nyu.edu
Purpose:
To determine the association of frequency of illegal drug use with five groups of factors: environmental stressors, parental drug use, parental child rearing, peer drug use, and adolescent personal attributes.
Methods:
1468 male (45%) and female (55%) adolescents, aged 12 to 17 years (mean 14.76, SD 1.51), were interviewed at home in Durban and Capetown, South Africa. Independent measures assessed environmental stressors, parental child rearing, parental drug use, peer drug use, and adolescent personal attributes. The dependent variable was the adolescents' frequency of illegal drug use.
Results:
Regression analyses showed that personal attributes and peer substance use explained the largest percentage of the variance in the adolescents' frequency of illegal drug use. In addition, both of the parental factors and the environmental stressors contributed to the explained variance in adolescent drug use above and beyond the two more proximal domains at a statistically significant level.
Conclusions:
Knowing the contribution of more proximal vs. more distal risk factors for illegal drug use is useful for prioritizing targets for interventions. Targeting changes in the more proximal predictors (e.g., adolescent personal attributes) may be more effective as well as more feasible than trying to produce changes in the more distal factors, such as environmental stressors.
Related Concept Videos
Drug Abuse and Addiction: Pharmacological Phenomena
Drug Toxicity: Risk factors
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Drug Dependence
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
Factors Affecting Drug Response: Overview
