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Updated: Aug 2, 2026

Establishment of an Oronasal Fistula Mice Model
Published on: September 8, 2023
Use of Palacos R-40 with gentamicin to reconstruct temporal defects after maxillofacial reconstructions with
S Wright1, F Bekiroglu, N M Whear
1Department of Oral & Maxillofacial Surgery, New Cross Hospital, Wolverhampton WV10 0QP, United Kingdom. addenbrookes@hotmail.com
Abstract:
The temporalis muscle flap is a useful flap for the reconstruction of oral ablative defects. A complication of its use that was overlooked was the crater-like defect created when the muscle is stripped from its attachment on the temporal fossa. The cold-cure acrylic we use is Palacos R-40 with Gentamicin (Heraeus Kulzer GmbH). This material is radio-opaque, rapidly setting and contains gentamicin. We present a total of 41 cases over an 11-year period (1994-2005). We have a 97.6% (n = 40) success rate. Infection developed in only one case, which leads to the removal of the acrylic implant. The use of Palacos R-40 with Gentamicin is easy to use, it can be custom-moulded to fit and fill the defect any of shape and size. It has minimal complications and high success rate with acceptable results to the patients.

