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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

Heart failure with a normal ejection fraction

J E Sanderson1

  • 1Department of Cardiology, University Hospital of North Staffordshire NHS Trust, City General Hospital, Stoke-on-Trent ST4 6QG, UK. John.Sanderson@uhns.nhs.uk

Heart (British Cardiac Society)
|January 3, 2006
PubMed

Insights

Heart failure with preserved ejection fraction (HFNEF) affects nearly half of patients. This review examines the epidemiology, causes, and pathophysiology of HFNEF, emphasizing the role of cardiac remodeling.

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Nearly 50% of heart failure patients exhibit normal left ventricular ejection fraction.
  • This condition is known by various terms, including diastolic heart failure and heart failure with preserved ejection fraction (HFNEF).

Purpose of the Study:

  • To review the epidemiology, etiology, and pathophysiology of HFNEF.
  • To highlight the significance of cardiac remodeling in differentiating between systolic heart failure and HFNEF.
  • To propose a more rational classification system for heart failure patients.

Main Methods:

  • Literature review of recent studies on HFNEF.
  • Analysis of the role of cardiac remodeling in heart failure presentation.
  • Discussion of the classification of heart failure based on pathophysiology.

Main Results:

  • HFNEF is the preferred term, as systolic function is not entirely normal in these patients.
  • Cardiac remodeling plays a crucial role in determining whether a patient develops systolic heart failure or HFNEF.

Conclusions:

  • HFNEF is a significant clinical entity requiring further understanding.
  • Cardiac remodeling offers a framework for a more rational classification of heart failure.
  • Further research into the pathophysiology and management of HFNEF is warranted.

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