Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Infection, inflammation, height, and longevity.

Eileen M Crimmins1, Caleb E Finch

  • 1Andrus Gerontology Center, College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, CA 90089-0191, USA. crimmin@usc.edu

Proceedings of the National Academy of Sciences of the United States of America
|January 3, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk and protective factors for cognitive decline in older adults from a nationally representative sample in India: Results from the LASI-DAD.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

An immune-associated mitochondrial DNA variant with sex differences reveals a putative novel microprotein called MASL.

Immunity & ageing : I & A·2026
Same author

Exceptionally low mortality despite widespread COVID-19 infection among Indigenous Tsimane and Moseten of Bolivia.

Social science & medicine (1982)·2026
Same author

Air pollution is linked to divergent cortical thickness patterns in brain regions vulnerable to Alzheimer's disease.

Neurotoxicology·2026
Same author

In memoriam: Thomas Eugene Johnson.

GeroScience·2026
Same author

Epigenetic aging and blood based neurodegeneration markers in LASI-DAD.

The journal of prevention of Alzheimer's disease·2026
Same journal

The TaMYB55-TaSnRK1α1-TabZIP9 module confers heat stress tolerance in wheat.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Superstatistics approach to turbulent circulation fluctuations.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

A molecular timescale for evolution of cobamide biosynthesis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Pierre Chambon, a pioneer of molecular biology and gene regulation in eukaryotes.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Granulosa cell glycogen fuels the avascular corpus luteum.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Synthetic essentiality of TRAIL/TNFSF10 in VHL-deficient renal cell carcinoma.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

Improved early life conditions led to longer lifespans and reduced mortality across all ages. This historical study links lower infection burdens to increased adult height and better elderly health outcomes.

Area of Science:

  • Historical epidemiology
  • Public health
  • Biomedical sciences

Background:

  • Examining historical demographic data from Northern European cohorts born before the 20th century.
  • Investigating the relationship between mortality rates at different life stages and physical development.

Observation:

  • Cohorts experiencing reduced mortality at younger ages also showed declining mortality in old age.
  • These same cohorts exhibited a concurrent increase in average adult height.

Findings:

  • A reduced burden of infections and inflammation is hypothesized as a common factor promoting both increased longevity and greater adult stature.
  • Early life environmental factors may influence both childhood development and the risk of age-related diseases like cardiovascular disease.

Related Experiment Videos

Implications:

  • Understanding the long-term impact of early life conditions on health and aging.
  • Suggests a potential link between early growth, reduced inflammation, and reduced risk of age-related diseases.
  • Highlights the importance of environmental factors in shaping population health trajectories over historical timescales.