Related Experiment Video
Updated: Aug 13, 2026

Prion Safety Laboratory Swipe Test
Published on: February 14, 2025
Psychiatric manifestations of Creutzfeldt-Jakob disease: a 25-year analysis
Christopher A Wall1, Teresa A Rummans, Allen J Aksamit
1Department of Psychiatry and Psychology, Mayo Clinic, Mayo Building-W11A, 200 First Street SW, Rochester, MN 55905, USA. wall.chris@mayo.edu
Abstract:
This study characterizes the type and timing of psychiatric manifestations in sporadic Creutzfeldt-Jakob disease (sCJD). Historically, sCJD has been characterized by prominent neurological symptoms, while the variant form (vCJD) is described as primarily psychiatric in presentation and course: A retrospective review of 126 sCJD patients evaluated at the Mayo Clinic from 1976-2001 was conducted. Cases were reviewed for symptoms of depression, anxiety, psychosis, behavior dyscontrol, sleep disturbances, and neurological signs during the disease course. Eighty percent of the cases demonstrated psychiatric symptoms within the first 100 days of illness, with 26% occurring at presentation. The most commonly reported symptoms in this population included sleep disturbances, psychotic symptoms, and depression. Psychiatric manifestations are an early and prominent feature of sporadic CJD, often occurring prior to formal diagnosis.
Related Concept Videos
Huntington Disease l: Introduction
Alzheimer Disease l: Introduction
Multiple Sclerosis l: Introduction
Cryptococcal Meningitis
Encephalitis l: Introduction
