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Dengue fever with acute liver failure
B N Vinodh1, C Bammigatti, Ashok Kumar
1Department of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110 029, India.
Journal of Postgraduate Medicine
|January 3, 2006
Summary
Dengue hemorrhagic fever, caused by Flaviviridae viruses, rarely presents as acute liver failure. This case study highlights a rare instance of severe dengue with liver failure and shock, successfully treated with supportive care.
Area of Science:
- Virology
- Infectious Diseases
- Hepatology
Background:
- Dengue hemorrhagic fever is a significant public health concern caused by Flaviviridae viruses.
- Dengue is endemic in India, with a major epidemic in Delhi in 2003.
- Acute liver failure is a rare but severe manifestation of dengue infection.
Observation:
- A 19-year-old male presented with prolonged fever during the 2003 Delhi dengue epidemic.
- The patient was diagnosed with dengue shock syndrome (Stage IV) and acute liver failure.
- This was identified as a primary dengue infection.
Findings:
- Dengue virus serotypes 2 and 3 were identified as the causative agents during the 2003 epidemic.
- The patient exhibited severe dengue with critical complications, including shock and acute liver failure.
- Complete recovery was achieved through comprehensive supportive management.
Implications:
- This case underscores the potential for dengue to cause severe liver injury and shock, even in primary infections.
- Highlights the importance of recognizing and managing rare, severe presentations of dengue.
- Emphasizes the effectiveness of supportive care in managing critical dengue cases, including those with acute liver failure.