Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Steroid preservation: the rationale for continued prescribing.

Stephen D Marks, Richard S Trompeter

    Pediatric Nephrology (Berlin, Germany)
    |January 3, 2006
    PubMed
    Summary

    Optimizing immunosuppression in pediatric renal transplantation is crucial. Steroid-free regimens are preferred to avoid side effects like growth retardation, but increase infection risks, including post-transplant lymphoproliferative disease (PTLD).

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same authorSame journal

    Paediatric lupus nephritis: defining remission and the evolving therapeutic landscape.

    Pediatric nephrology (Berlin, Germany)·2026
    Same author

    Executive Summary: The 2026 British Society for Rheumatology guideline for the management of children, young people and adults with systemic lupus erythematosus.

    Rheumatology (Oxford, England)·2026
    Same author

    The 2026 British Society for Rheumatology guideline for the management of children, young people and adults with systemic lupus erythematosus.

    Rheumatology (Oxford, England)·2026
    Same author

    Identifying strategies to improve life participation in children with chronic kidney disease: report from multinational SONG workshops.

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
    Same author

    Triple Therapy With Calcineurin Inhibition Enhances Remission in Childhood-Onset Lupus Nephritis.

    Kidney international reports·2026
    Same author

    Kidney Transplantation in Childhood-Onset ANCA-Associated Vasculitis: Long-Term Outcomes and Prognostic Factors.

    Clinical journal of the American Society of Nephrology : CJASN·2026

    Area of Science:

    • Pediatric Nephrology
    • Transplantation Immunology

    Background:

    • Renal allograft survival necessitates tailored immunosuppression to mitigate immunological and non-immunological risks.
    • Corticosteroids, while effective, cause significant side effects in children, including growth retardation and cosmetic issues.

    Discussion:

    • Modern immunosuppression strategies aim to reduce acute rejection but may increase the risk of infections, notably Epstein-Barr virus (EBV) and post-transplant lymphoproliferative disease (PTLD).
    • The shift from acute rejection to infection as a primary concern highlights the evolving challenges in pediatric renal transplantation.

    Key Insights:

    • Steroid-free immunosuppressive regimens are desirable for pediatric renal transplant recipients to minimize adverse effects.
    • Balancing the prevention of rejection with the management of infection, particularly EBV-related PTLD, is a critical challenge.

    Related Experiment Videos

    Outlook:

    • Further research is needed to understand the long-term outcomes of PTLD in patients on steroid-free and monoclonal antibody protocols.
    • Developing novel immunosuppressive strategies that minimize both rejection and infection risks remains a key objective.