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Hemoglobin and atherosclerosis in patients with manifest arterial disease. The SMART-study

J M Dijk1, G Wangge, Y van der Graaf

  • 1Julius Center for Health Sciences and Primary Care, University, Medical Center Utrecht (UMCU), Utrecht, The Netherlands.

Atherosclerosis
|January 4, 2006
PubMed

Insights

Higher hemoglobin levels are linked to reduced atherosclerosis severity in patients with existing arterial disease. This suggests a potential protective role of hemoglobin in vascular health.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Hematology

Background:

  • Low hemoglobin levels correlate with increased coronary mortality and morbidity, potentially due to left ventricular hypertrophy.
  • Vessel wall remodeling mechanisms implicated in atherosclerosis may also be influenced by hemoglobin levels.

Purpose of the Study:

  • To investigate the relationship between hemoglobin levels and various vascular indicators of atherosclerosis in patients with manifest arterial disease.

Main Methods:

  • Cross-sectional study of 2514 patients with manifest arterial disease from the SMART-study.
  • Assessed associations between hemoglobin levels and common carotid intima-media thickness (CIMT), internal carotid artery stenosis (ICAS), and peripheral arterial disease (PAD) using regression analyses.

Main Results:

  • Each mmol/l increase in hemoglobin was associated with significantly lower CIMT and reduced prevalence of significant ICAS.
  • No significant association was found between hemoglobin levels and the prevalence of peripheral arterial disease.

Conclusions:

  • Increasing hemoglobin levels are associated with reduced atherosclerosis severity in patients with manifest arterial disease.
  • These findings highlight a potential link between hemoglobin levels and the progression of atherosclerosis.
Abstract

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