Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mild forced treadmill exercise enhances spatial learning in the aged rat.

David S Albeck1, Kazuhiro Sano, Gayle E Prewitt

  • 1Department of Psychology, University of Colorado at Denver, Campus Box 173, P.O. Box 173364, Denver, CO 80217-3364, USA. David.Albeck@cudenver.edu

Behavioural Brain Research
|January 4, 2006
PubMed
Summary

Mild treadmill exercise improved spatial learning in aged rats, but did not alter neurotrophin levels in the basal forebrain (BF). This suggests exercise benefits learning independently of BF neurotrophin changes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estrous Cycle-Dependent Modulation of Sexual Receptivity in Female Mice by Estrogen Receptor Beta-Expressing Cells in the Dorsal Raphe Nucleus.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2024
Same author

In ovo o,p'-DDT exposure induces malformation of reproductive organs and alters the expression of genes controlling sexual differentiation in Japanese quail embryo.

Journal of applied toxicology : JAT·2023
Same author

Estrogen Receptor β in the Lateral Septum Mediates Estrogen Regulation of Social Anxiety-like Behavior in Male Mice.

Neuroscience·2023
Same author

Activity of estrogen receptor β expressing neurons in the medial amygdala regulates preference toward receptive females in male mice.

Proceedings of the National Academy of Sciences of the United States of America·2023
Same author

Sex and age differences in the distribution of estrogen receptors in mice.

Neuroscience letters·2022
Same author

Estrogenic action by tris(2,6-dimethylphenyl) phosphate impairs the development of female reproductive functions.

Environment international·2020

Area of Science:

  • Neuroscience
  • Exercise Physiology
  • Aging Research

Background:

  • Neurotrophin deficits in the basal forebrain (BF) are linked to Alzheimer's disease.
  • Physical exercise is known to increase neurotrophin levels.
  • The impact of mild exercise on BF neurotrophins and learning in aged subjects requires further investigation.

Purpose of the Study:

  • To determine if mild, forced treadmill exercise enhances learning in aged rats.
  • To investigate whether such exercise increases neurotrophin levels in the basal forebrain (BF).

Main Methods:

  • Aged rats underwent 7 weeks of mild, forced treadmill exercise.
  • Spatial learning was assessed using a hidden platform task.
  • Neurotrophin levels in the basal forebrain were measured.

Related Experiment Videos

Main Results:

  • Exercised rats learned the hidden platform location significantly faster than control rats (p<0.05).
  • Exercised rats exhibited shorter pathlengths during the task (p<0.05).
  • No significant differences in swim speed or basal forebrain neurotrophin levels were observed between groups.

Conclusions:

  • Mild treadmill exercise improves spatial learning and memory in aged rats.
  • The learning benefits of exercise in this model may occur independently of changes in basal forebrain neurotrophin levels.
  • Further research is needed to elucidate the mechanisms underlying exercise-induced cognitive improvements in aging.