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Updated: Aug 13, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Mathematical modeling of arterial pressure response to hemodialysis-induced hypovolemia
Silvio Cavalcanti1, Silvia Cavani, Andrea Ciandrini
1Department of Electronics, Computer Science and Systems, Biomedical Engineering Laboratory, University of Bologna, Italy. scavalcanti@deis.unibo.it
Abstract:
A computer model of pressure response to hemodialysis-induced hypovolemia is reported. Heart rate and hematocrit, measured in the course of hemodialysis, are imposed as computer model inputs and the model computes the arterial pressure response after tuning model parameters representative of patient's cardiovascular reactivity. Computer model reproduced with good accuracy experimental data (arterial pressure, cardiac output and total peripherical resistance). Parameter identification over successive sessions of the same patients revealed satisfactory reliability, providing a physiological interpretative key to patient's hemodynamic behavior during hemodialysis.
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