Related Experiment Videos
Molecular pharmacology of cocaine: a dopamine hypothesis and its implications
1Neuroscience Branch, Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224.
Ciba Foundation Symposium
|January 1, 1992
Abstract:
The reinforcing properties of cocaine have been related to cocaine binding at the dopamine transporter in mesolimbocortical neurons. The molecular properties of the transporter have been studied in a number of laboratories. While this 'dopamine hypothesis' is strongly supported in animal studies of drug self-administration, the extent of its involvement in human drug dependence has not been fully elucidated.