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Updated: Aug 13, 2026

Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
Mesenteric ischemia
Michael Ujiki1, Melina R Kibbe
1Division of Vascular Surgery, Northwestern University, Chicago, IL 60611, USA.
Abstract:
Mesenteric ischemia is a morbid, potentially life-threatening disease that is associated with a relatively high mortality, often due to its late diagnosis. Currently, the incidence of mesenteric ischemia in the United States is low; however, the incidence is predicted to increase because of the aging population. Therefore, whether the presentation is acute or chronic in nature, the challenge for the physician remains early diagnosis through a high index of suspicion based on vague and often atypical presentations. Surgical intervention remains the mainstay of therapy. Despite ongoing investigations of the different treatment options, including single vs multivessel bypass, antegrade vs retrograde graft placement, autogenous vs prosthetic conduits, and endovascular vs open surgical repair, many questions remain unanswered. This review summarizes the clinical presentation, diagnosis, and treatment options, including both open and endovascular approaches, for acute and chronic mesenteric ischemia.
Insights
Early diagnosis of mesenteric ischemia is crucial due to high mortality, often caused by delayed detection. This review covers diagnosis and treatment options for acute and chronic mesenteric ischemia, emphasizing early suspicion.
Area of Science:
- Vascular Surgery
- Gastroenterology
Background:
- Mesenteric ischemia presents a significant mortality risk, frequently linked to delayed diagnosis.
- The incidence of mesenteric ischemia is projected to rise with an aging population.
- Vague and atypical symptoms complicate early detection, necessitating a high index of suspicion.
Purpose of the Study:
- To review the clinical presentation of mesenteric ischemia.
- To summarize diagnostic strategies for acute and chronic mesenteric ischemia.
- To outline current and investigational treatment options, including open and endovascular approaches.
Main Methods:
- Literature review of clinical presentations.
- Analysis of diagnostic modalities.
- Synthesis of treatment strategies for mesenteric ischemia.
Main Results:
- Late diagnosis remains a primary driver of mortality in mesenteric ischemia.
- Both acute and chronic forms present diagnostic challenges.
- Surgical intervention is the primary treatment, with ongoing debate on optimal techniques.
Conclusions:
- Early diagnosis of mesenteric ischemia is critical for improving patient outcomes.
- A high index of suspicion is essential for timely identification.
- This review provides a comprehensive overview of current management strategies.
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