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Published on: June 20, 2018
From sequences to a functional unit
Ashwin Sivakumar1, Christopher Wilton, Liisa Holm
1Institute of Biotechnology, Department of Genetics, University of Helsinki, Helsinki, Finland. ashwin.sivakumar@helsinki.fi
Abstract:
Functional insights at the gene product level would help the drug discovery industry to effectively tap targets for therapeutics and biomedical applications. A complete functional unit can be multidomain, and it is the co-occurrence and interaction of these multiple domains that determine the function and functional diversity of their gene products. With at least 10% of genes from complete genomes existing in fused form, identifying gene fusion events helps us categorize the protein universe into distinct functional units with only sequence information.
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