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Related Experiment Videos

From sequences to a functional unit.

Ashwin Sivakumar1, Christopher Wilton, Liisa Holm

  • 1Institute of Biotechnology, Department of Genetics, University of Helsinki, Helsinki, Finland. ashwin.sivakumar@helsinki.fi

Physiological Genomics
|January 5, 2006
PubMed
Summary

Identifying gene fusion events is crucial for understanding gene product functions. This helps the drug discovery industry find new therapeutic targets by analyzing protein domains and their interactions.

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Area of Science:

  • Genomics
  • Proteomics
  • Bioinformatics

Background:

  • Understanding gene product function is vital for drug discovery and biomedical applications.
  • Multidomain proteins form functional units through the co-occurrence and interaction of their domains.
  • Gene fusion events are prevalent, with at least 10% of genes in complete genomes existing in fused forms.

Purpose of the Study:

  • To highlight the importance of functional insights at the gene product level.
  • To emphasize the role of multidomain protein architecture in determining function.
  • To establish gene fusion identification as a method for categorizing the protein universe.

Main Methods:

  • Analysis of gene sequences from complete genomes.
  • Identification of gene fusion events.

Related Experiment Videos

  • Characterization of protein domain co-occurrence and interactions.

    • Main Results:

    • Gene fusion events are common in complete genomes.
    • Identifying these fusions aids in classifying proteins into functional units.
    • Sequence information alone can be leveraged for this categorization.

    Conclusions:

    • Gene fusion identification is a powerful tool for functional genomics.
    • This approach facilitates the categorization of the protein universe.
    • It provides a foundation for identifying novel therapeutic and biomedical targets.