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Published on: January 12, 2024
Primary intraocular lymphoma arising during methotrexate treatment of temporal arteritis
Kamilia Rizkalla1, Sylvia Rodrigues, Alain Proulx
1Department of Pathology, University of Western Ontario, London, Ont.
Case Report:
Primary intraocular lymphoma arose over a period of 9 months in the left eye of an 81-year-old woman who was blind in both eyes from temporal arteritis. During this period, she was treated with prednisone and methotrexate. Following a sudden total hyphema, the eye was enucleated. Examination revealed that, in addition to iris neovascularisation and central retinal artery occlusion, the neurosensory retina was replaced by atypical lymphocytes.
Comments:
Histological and immunohistochemical studies confirmed the presence of a lymphoma with features indicative of an immunosuppression-related disorder. The relationship of the lymphoma to the vascular changes within the eye is discussed.
