Study focuses in on potential cause of antipsychotic-induced diabetes

First-generation antipsychotic drugs, efficacious in reducing the "positive" syndrome of schizophrenia, carried serious motor side effects, such as immobility and Parkinsonism. While second-generation antipsychotics have reduced the incidence of such effects, they are not without risk. It has come to light that both first- and second-generation antipsychotics are associated with weight gain and type 2 diabetes. This short review addresses this issue, as well as covers recent studies to find which neurotransmitter receptors may be involved in the induction of these metabolic disturbances.