Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Prokaryotic polyprotein precursors.

L Thöny-Meyer¹, A Böck, H Hennecke

¹Mikrobiologisches Institut, Eidgenössische Technische Hochschule, ETH-Zentrum, Zürich, Switzerland.

|July 27, 1992

Summary

Bacterial polyproteins, precursors processed into multiple proteins, are newly discovered in prokaryotes. This study examines their genomic organization, processing sites, proteases, maturation, and functions, exploring their evolutionary origins.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Accuracy and clinical outcomes of mandibular reconstruction with a virtually planned deep circumflex iliac artery flap with stock temporomandibular joint prosthesis.

International journal of oral and maxillofacial surgery·2024

Same author

Evaluation of a novel osteosynthesis plate system for mandibular defects.

The British journal of oral & maxillofacial surgery·2020

Same author

Influence of bone density, screw size and surgical procedure on orthodontic mini-implant placement - part B: implant stability.

International journal of oral and maxillofacial surgery·2020

Same author

Aesthetic aspects of adjacent maxillary single-crown implants-influence of zirconia and titanium as implant materials.

International journal of oral and maxillofacial surgery·2020

Same author

"Flipped OR": a modified didactical concept for a surgical clerkship in Oral and Maxillofacial Surgery.

The British journal of oral & maxillofacial surgery·2020

Same author

Evaluation of the bactericidal effect of cold atmospheric pressure plasma on contaminated human bone: an in vitro study.

The British journal of oral & maxillofacial surgery·2020

Area of Science:

Molecular Biology
Genetics
Biochemistry

Background:

Polyproteins, precursors cleaved into mature proteins, were previously unknown in prokaryotes.
Recent discoveries reveal polyproteins exist in bacteria, challenging earlier assumptions.

Purpose of the Study:

To comprehensively analyze known bacterial polyproteins.
To investigate their genetic basis, processing mechanisms, and functional significance.
To explore the evolutionary pathways leading to bacterial polyproteins.

Main Methods:

Genomic analysis of bacterial polyprotein genes.
Identification of proteolytic cleavage sites.
Characterization of involved proteases.
Elucidation of protein maturation pathways.
Functional analysis of mature proteins.

Main Results:

Four distinct examples of bacterial polyproteins were identified.
Detailed information on their genomic arrangement and processing sites was gathered.
The specific proteases responsible for cleavage were identified.
Maturation pathways and the functions of the resulting mature proteins were described.

Conclusions:

Bacterial polyproteins represent a novel mechanism for gene expression in prokaryotes.
Understanding these systems provides insights into protein maturation and evolution.
Further research is warranted to uncover more examples and their roles.

Related Experiment Videos