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Updated: Aug 13, 2026

Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete
Published on: January 24, 2025
Secondary pulmonary syphilis: report of a likely case and literature review
Gary David1, Thomas Perpoint, André Boibieux
1Department of Infectious Diseases, Croix-Rousse University Hospital, Lyon, France. gary.david@chu-lyon.fr
Abstract:
We report the case of a homosexual, HIV-positive man with typical secondary syphilis and multiple excavated pulmonary subpleural nodules. Syphilis with direct pulmonary involvement was suggested by a positive result of PCR of a bronchoalveolar lavage fluid specimen, then confirmed by a positive therapeutic test result. Only 9 reports of pulmonary involvement in secondary syphilis have been reported to date in the English-language literature. Clinicians should be aware of this atypical localization of syphilis.
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