Related Experiment Video
Updated: Aug 13, 2026

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
Published on: December 27, 2016
[Dose-dependent effect of penicillin on activity of metabolic enzymes in Staphylococcus epidermidis]
Abstract:
The study was concerned with investigation of the biochemical properties, antibiotic resistance and the effect of various doses of penicillin on the activity of metabolic enzymes in the bacterial cells of Staphylococcus epidermidis isolated from the pharynx mucosa of healthy subjects. The study revealed an increase in the aggressive properties of the representatives of the mouth normal microflora. It was also observed that the highest percentage of the staphylococcal isolates was resistant to beta-lactam antibiotics. The effect of various concentrations of penicillin on the microbial metabolism was shown to be directed at different targets. Penicillin intensified the aerobic processes and lipid synthesis in the bacterial cells. The reactions of the processes of the amino acid metabolism proceeded in different directions. Some concentrations of penicillin inhibited such processes.
More Related Videos
06:36Improved Enzyme Protection Assay to Study Staphylococcus aureus Internalization and Intracellular Efficacy of Antimicrobial Compounds
Published on: September 8, 2021
07:28Metabolic Profiling to Determine Bactericidal or Bacteriostatic Effects of New Natural Products using Isothermal Microcalorimetry
Published on: October 29, 2020
Related Concept Videos
Production of Antibiotics
Mechanism of Antibiotic Resistance in MRSA
Inhibitors of Gram-positive Cell Wall Synthesis
Pharmacokinetic–Pharmacodynamic Relationship: Influence of Elimination Half-Life on Effect Duration
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Development of Antibiotic Resistance