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Effect of hypolipidemic drugs on cholinesterase activity in the rat
E Kunec-Vajić1, N Bernat, D Muacević-Katanec
1Department of Pharmacology, Faculty of Medicine, University of Zagreb, Yugoslavia.
Abstract:
1. The effect of four hypolipidemic agents with different mechanisms of action (fenofibrate, probucol, colestipol and nicotinic acid) on plasma and liver cholinesterase has been studied. 2. Liver weight and liver weight/body weight ratio increased only after treatment with fenofibrate. 3. Plasma and liver cholinesterase activity increased markedly after fenofibrate, a strong peroxisome proliferator, and slightly after nicotinic acid, a weak peroxisome proliferator. 4. The data obtained suggest that increased cholinesterase activity is due to increased rate of fatty acid oxidation caused by peroxisome proliferators.