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Age-related changes in cognitive domains. A population-based study.

Angelo Scuteri1, Luigi Palmieri, Cinzia Lo Noce

  • 1Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanità, Roma, Italy. angeloelefante@interfree.it

Aging Clinical and Experimental Research
|January 6, 2006
PubMed
Summary

Cognitive decline in elderly men accelerates after age 85, affecting global cognition, executive function, and motor speed. These age-related changes are independent of education, depression, or cerebrovascular accidents.

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Area of Science:

  • Gerontology
  • Neuroscience
  • Cognitive Psychology

Background:

  • Aging impacts cognitive domains including global cognitive function, executive function, and motor speed.
  • Factors such as education, depression, and cerebrovascular accidents (CEVD) may influence age-related cognitive changes.

Purpose of the Study:

  • To examine the effects of aging on cognitive domains in elderly men.
  • To investigate the influence of education, depression, and CEVD on age-related cognitive decline.

Main Methods:

  • Cross-sectional observational study of 334 men aged 65-95.
  • Cognitive function assessed using Mini-Mental State Examination (MMSE), Stroop test, and Purdue Pegboard test.
  • Depression measured by CES-D test; CEVD, medical history, and lifestyle factors evaluated.

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Main Results:

  • Significant age-associated decline observed in global cognitive functions, executive functions, and motor speed.
  • Cognitive decline became more pronounced after age 85 for MMSE and after age 75 for executive functions and motor speed.
  • Age remained an independent predictor of cognitive decline, irrespective of education, depression, or CEVD.

Conclusions:

  • Age-related cognitive decline in community-dwelling elderly men is evident, particularly after age 85.
  • These cognitive changes are not significantly influenced by educational attainment, depressive symptoms, or prevalent CEVD.