Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The beneficial helminth parasite?

D M McKay1

  • 1Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada. mckayd@mcmaster.ca

Parasitology
|January 6, 2006
PubMed
Summary

Helminth infections modulate host immunity, potentially blocking other diseases. Understanding this immune regulation could lead to new therapies for autoimmune and allergic conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Triggering immunological memory against the tapeworm Hymenolepis diminuta to protect against colitis.

Parasite immunology·2017
Same author

Suppression of colitis by adoptive transfer of helminth antigen-treated dendritic cells requires interleukin-4 receptor-α signaling.

Scientific reports·2017
Same author

Vasoactive intestinal polypeptide regulates barrier function via mast cells in human intestinal follicle-associated epithelium and during stress in rats.

Neurogastroenterology and motility·2013
Same author

In vitro anaerobic biofilms of human colonic microbiota.

Journal of microbiological methods·2010
Same author

Extracts of the rat tapeworm, Hymenolepis diminuta, suppress macrophage activation in vitro and alleviate chemically induced colitis in mice.

Infection and immunity·2009
Same author

Salvinorin A inhibits colonic transit and neurogenic ion transport in mice by activating kappa-opioid and cannabinoid receptors.

Neurogastroenterology and motility·2009

Area of Science:

  • Immunology
  • Parasitology
  • Epidemiology

Background:

  • Parasites, particularly helminths, significantly influence host immune activity.
  • Helminth infections are linked to reduced incidences of autoimmune and allergic diseases globally.

Purpose of the Study:

  • To review and assess mechanisms by which helminth infections modulate concomitant disease processes.
  • To explore the potential for developing helminth-based therapies for inflammatory disorders.

Main Methods:

  • Review of epidemiological studies on helminth infection prevalence and disease incidence.
  • Analysis of immunoregulatory processes in helminth-infected rodents and humans.

Main Results:

  • Helminth infections can impact the induction and progression of other diseases in hosts.
  • Regions with high helminth infection rates show lower occurrences of autoimmune and allergic conditions.

Conclusions:

  • Further research into helminth-induced immunomodulation is crucial.
  • Understanding these mechanisms may yield novel interventions for autoimmune and allergic diseases.
  • Helminth therapy presents a potential treatment strategy for specific inflammatory disorders.

Related Experiment Videos