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Is liquid-based pap testing affected by water-based lubricant?

Jon K Hathaway¹, Pramod K Pathak, Rhonda Maney

¹Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University and Sparrow Hospital, Lansing, Michigan 48909, USA. Jon.Hathaway@byu.net

Obstetrics and Gynecology

|January 6, 2006

Summary

This summary is machine-generated.

Water-based lubricant does not impact liquid-based Pap test results or secondary diagnoses like yeast infections. This study found no significant difference in abnormal cytology rates when lubricant was used.

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Area of Science:

Gynecologic cytology
Diagnostic accuracy

Background:

Liquid-based cytology is a common method for cervical cancer screening.
The potential impact of lubricants on test accuracy is a clinical concern.

Purpose of the Study:

To evaluate the effect of water-based lubricant on liquid-based Pap test cytology.
To assess lubricant's influence on secondary diagnoses in Pap tests.

Main Methods:

200 women underwent simultaneous Pap test collections.
One specimen was intentionally contaminated with water-based lubricant post-collection.
Cytopathologists analyzed specimens, blinded to contamination status.

Main Results:

Abnormal cytology rates were similar between lubricant-contaminated (6.5%) and control (7.0%) specimens.
Discordance rate between paired specimens was 7.5%, comparable to conventional methods.
Secondary diagnoses (yeast, bacterial vaginosis) showed no significant difference.

Conclusions:

Water-based lubricant does not adversely affect liquid-based Pap test results.
Lubricant use does not interfere with the detection of common secondary diagnoses.