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Gene-dosage mapping of 30 DNA markers on chromosome 21
J M Delabar1, Z Chettouh, Z Rahmani
1URA CNRS 1335, Hôpital Necker, Paris, France.
Genomics
|July 1, 1992
Abstract:
Using a slot-blot method for the dosage of single-copy sequences, the copy numbers of 30 chromosome 21 markers were assessed in the blood DNA of 11 patients with partial trisomy or monosomy 21 and in the DNA of a patient-derived human-hamster hybrid cell line carrying a microduplication of chromosome 21. The physical order of these markers on chromosome 21 was thereby determined.