Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An algorithm for analyzing linkages affected by heterozygous translocations: QuadMap.

J D Durrant1, B W Gardunia, K D Livingstone

  • 1Department of Plant and Animal Sciences, 275 WIDB, Brigham Young University, Provo, UT 84602, USA.

The Journal of Heredity
|January 6, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-molecule sequencing and Hi-C-based proximity-guided assembly of amaranth (Amaranthus hypochondriacus) chromosomes provide insights into genome evolution.

BMC biology·2017
Same author

The Amaranth Genome: Genome, Transcriptome, and Physical Map Assembly.

The plant genome·2016
Same author

Maximum Permissible Ambient Noise Levels for Audiometric Test Rooms.

American journal of audiology·2015
Same author

Identification of homoeologous chromosomes in hexaploid oat (A. byzantina cv Kanota) using monosomics and RFLP analysis.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
Same author

Mapping the Sw-5 locus for tomato spotted wilt virus resistance in tomatoes using RAPD and RFLP analyses.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
Same author

C-banding variation in the Moroccan oat species Avena agadiriana (2n=4x=28).

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
Same journal

Rapid Derivation of Cloning-Competent Cells from Peripheral Blood Advances Conservation Biobanking.

The Journal of heredity·2026
Same journal

Genomic vulnerability to climate change of a poorly dispersing and threatened fish, the southern pygmy perch (Nannoperca australis).

The Journal of heredity·2026
Same journal

The complete genomes of two hybridizing field crickets, Gryllus pennsylvanicus and Gryllus firmus.

The Journal of heredity·2026
Same journal

Chromosome-level genome assembly and annotation of the transverse lady beetle Coccinella transversoguttata.

The Journal of heredity·2026
Same journal

A Chromosome-Level Assembly of the Pine Processionary Moth (Thaumetopoea pityocampa) genome.

The Journal of heredity·2026
Same journal

An annotated, chromosome-level genome for the spotted turtle, Clemmys guttata.

The Journal of heredity·2026
See all related articles

Researchers developed new methods to improve the accuracy of genetic linkage maps for individuals with reciprocal translocations. This new software, QuadMap, helps distinguish the four segments involved in these complex chromosome rearrangements.

Area of Science:

  • Genetics
  • Bioinformatics
  • Computational Biology

Background:

  • Heterozygous chromosome rearrangements, specifically reciprocal translocations, pose challenges for standard genetic linkage mapping.
  • Existing one-dimensional mapping software often misrepresents translocations as marker clusters, obscuring their true chromosomal origin.

Purpose of the Study:

  • To improve the accuracy of genetic linkage maps for regions affected by heterozygous reciprocal translocations.
  • To introduce a novel software application, QuadMap, for enhanced translocation mapping.

Main Methods:

  • Statistical methods utilizing variance in map distance to differentiate translocation segments.
  • Modifications to existing protocols, specifically the Livingstone et al. (2000) method.
  • Development and application of the QuadMap software for analyzing translocation-affected linkage maps.

Related Experiment Videos

Main Results:

  • The study presents refined statistical approaches for mapping complex chromosomal rearrangements.
  • QuadMap effectively dissects heterozygous translocation-affected linkage maps, providing more accurate representations.
  • The developed methods improve the resolution of genetic mapping in the presence of translocations.

Conclusions:

  • Accurate genetic mapping of reciprocal translocations requires specialized approaches beyond standard one-dimensional methods.
  • The QuadMap software offers a valuable tool for researchers studying chromosome rearrangements.
  • Improved mapping accuracy facilitates a better understanding of the genetic consequences of translocations.