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Eosinophilic leukemoid reaction associated with carbamazepine hypersensitivity
1Department of Skin and VD, Goa Medical College and Hospitals, Bambolim, Goa, India. gaurishlaad@indiatimes.com
Indian Journal of Dermatology, Venereology and Leprology
|January 6, 2006
Summary
Carbamazepine, an epilepsy drug, can cause severe skin reactions like erythroderma and eosinophilia. Prompt steroid treatment resolved these adverse drug reactions in a rare Indian case.
Area of Science:
- Pharmacology
- Dermatology
- Hematology
Background:
- Carbamazepine is a common antiepileptic and mood-stabilizing drug.
- Adverse drug reactions, including skin manifestations and hematological changes, are known side effects.
- Drug hypersensitivity syndrome is a serious concern associated with carbamazepine.
Observation:
- A 50-year-old male developed generalized erythroderma after 10 weeks of carbamazepine use for epilepsy.
- Blood tests showed significant eosinophilia (52%).
- Bone marrow examination indicated increased eosinophils with normal morphology.
Findings:
- The patient presented with generalized erythroderma and marked eosinophilia.
- Eosinophil counts normalized within two weeks of initiating oral prednisolone therapy.
- This case highlights a rare presentation of carbamazepine-induced hypersensitivity.
Implications:
- Early recognition and management of carbamazepine-induced hypersensitivity are crucial.
- Corticosteroids appear effective in treating carbamazepine-induced erythroderma and eosinophilia.
- This case underscores the importance of considering drug reactions in patients presenting with dermatological and hematological abnormalities.
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