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Photodynamic therapy in dermatology.

Chitra S Nayak¹

¹Department of Dermatology, BYL Nair Hospital and TN Medial College, Mumbai, India. chitra1202@yahoo.co.in

Indian Journal of Dermatology, Venereology and Leprology

|January 6, 2006

Summary

Photodynamic therapy (PDT) offers a promising new treatment for various skin tumors and dermatological conditions. This innovative approach utilizes a photosensitizer, oxygen, and light to effectively treat conditions like basal cell carcinoma with minimal side effects.

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Area of Science:

Oncology
Dermatology
Photomedicine

Background:

Photodynamic therapy (PDT) is an emerging treatment modality for various tumors.
Its application is expanding, particularly in treating skin tumors and dermatological disorders.
PDT is recognized for its potential as a future therapeutic option.

Purpose of the Study:

To review the mechanism, applications, and outcomes of photodynamic therapy in dermatology.
To highlight the efficacy and safety of PDT for specific skin conditions.
To discuss the potential of novel photosensitizers in enhancing PDT outcomes.

Main Methods:

The mechanism of action involves a Type II photo-oxidative reaction.
Key variables include the choice of photosensitizer, tissue oxygenation levels, and the light source.
Treatment efficacy is evaluated for various dermatological conditions.

Main Results:

PDT has demonstrated effectiveness in treating conditions such as Bowen's disease, actinic keratoses, squamous cell carcinomas, basal cell carcinomas, and mycosis fungoides.
Reported side-effects are generally mild and transient.
Newer photosensitizers, like methyl aminolevulinate, show significant promise for improved therapeutic results.

Conclusions:

Photodynamic therapy is a versatile and effective treatment for a range of skin cancers and dermatological diseases.
The therapy is well-tolerated, with manageable side effects.
Advancements in photosensitizer technology are expected to further enhance the clinical utility of PDT.

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