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Related Experiment Videos

Post-kala-azar dermal leishmaniasis: a histopathological study.

Sanjay K Rathi1, R K Pandhi, P Chopra

  • 1Department of Dermatology, All India Institute of Medical Sciences, New Delhi, India. srathi2@rediffmail.com

Indian Journal of Dermatology, Venereology and Leprology
|January 6, 2006
PubMed
Summary

Post-kala-azar dermal leishmaniasis (PKDL) presents with distinct histopathological features. Leishmania donovani bodies (LDBs) are infrequently found in PKDL lesions, especially in hypopigmented macules.

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Parasitology

Background:

  • Post-kala-azar dermal leishmaniasis (PKDL) is a sequel to visceral leishmaniasis.
  • Caused by the same pathogen, Leishmania donovani.

Purpose of the Study:

  • To evaluate epidermal and dermal changes in PKDL.
  • To determine the presence of Leishmania donovani bodies (LDBs) in PKDL lesions.

Main Methods:

  • Biopsy specimens from 25 clinically diagnosed PKDL patients were analyzed.
  • Histopathological examination focused on epidermal/dermal changes and LDB detection.

Main Results:

  • Hypopigmented macules showed perivascular infiltrate; no LDBs detected.
  • Nodular/plaque lesions exhibited diffuse infiltrate beneath atrophic epidermis with follicular plugging.

Related Experiment Videos

  • LDBs were found in 43.5% of nodular/plaque biopsies, but were not numerous.

    • Conclusions:

    • Histopathological features of PKDL are clarified.
    • The study elucidates diagnostic criteria for PKDL.