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Does nitric oxide regulate skeletal muscle glucose uptake during exercise?

Glenn K McConell1, Bronwyn A Kingwell

  • 1Department of Physiology, The University of Melbourne, Parkville, Australia. mcconell@unimelb.edu.au

Exercise and Sport Sciences Reviews
|January 6, 2006
PubMed
Summary

Nitric oxide (NO) plays a role in how skeletal muscles take up glucose during exercise, despite conflicting animal study results. This review explores the human evidence and factors influencing NO production in muscles.

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Area of Science:

  • Exercise Physiology
  • Metabolic Regulation
  • Biochemistry

Background:

  • Contradictory findings exist regarding nitric oxide (NO) involvement in skeletal muscle glucose uptake.
  • Emerging human studies suggest a significant role for NO in exercise-induced glucose metabolism.

Purpose of the Study:

  • To review the current evidence on nitric oxide's role in human skeletal muscle glucose uptake during exercise.
  • To discuss potential upstream regulators of nitric oxide synthase (NOS) in skeletal muscle.

Main Methods:

  • Literature review of human and rodent studies.
  • Analysis of evidence for nitric oxide's involvement in glucose transport.

Main Results:

  • Accumulating human data support NO's role in skeletal muscle glucose uptake during physical activity.

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  • Rodent study results remain inconsistent, highlighting species differences or experimental variations.

    • Conclusions:

    • Nitric oxide is likely involved in regulating glucose uptake in human skeletal muscle during exercise.
    • Further research is needed to elucidate the upstream mechanisms controlling skeletal muscle NOS activity.