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Related Experiment Videos

Acute cyanide poisoning.

Stacie B Peddy1, Mark R Rigby, Donald H Shaffner

  • 1Johns Hopkins University School of Medicine, Baltimore, MD, USA. speddy@jhmi.edu

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
|January 6, 2006
PubMed
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Cyanide poisoning is a rare but life-threatening condition. Early recognition and antidote therapy are crucial for critically ill patients to reduce severe outcomes.

Area of Science:

  • Toxicology
  • Emergency Medicine
  • Critical Care

Background:

  • Cyanide intoxication is a rare clinical event.
  • Prompt diagnosis and treatment are vital for patient survival.

Observation:

  • A 17-year-old male presented with seizures, apnea, and cardiovascular collapse.
  • Laboratory findings included profound anion gap metabolic acidosis and elevated lactate levels.

Findings:

  • The patient received cyanide antidote therapy for suspected poisoning.
  • Antidote infusions were discontinued due to methemoglobinemia.
  • The patient experienced irreversible neurological damage and was declared brain dead.

Implications:

  • This case highlights the critical importance of considering cyanide poisoning in undifferentiated critical illness.

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  • Early recognition and intervention with specific antidotes can potentially mitigate severe morbidity and mortality.
  • Further research into optimal antidote dosing and management strategies in pediatric cyanide poisoning is warranted.