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[Recurrent toxoplasmic retinochoroiditis after clindamycin treatment]
Z Benzina1, S Chaabouni, N Hentati
1Service d'Ophtalmologie, Hôpital Habib Bourguiba, 3029 Sfax, Tunisia. zeineb.benzina@rns.tn
Journal Francais D'Ophtalmologie
|January 6, 2006
Summary
Subconjunctival clindamycin injections with oral steroids effectively treat toxoplasmic retinochoroiditis (TRC), showing good tolerance and reduced recurrence rates compared to traditional therapies.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Pharmacology
Background:
- Toxoplasmic retinochoroiditis (TRC) is an ocular infection requiring effective treatment to prevent vision loss.
- Traditional treatment protocols for TRC have reported high recurrence rates.
Observation:
- This study evaluated 21 patients with unilateral TRC treated with subconjunctival clindamycin and oral corticosteroids.
- Clinical improvement was observed in 68.75% within 4 days, with complete healing in all patients within 1.6 months.
Findings:
- The treatment regimen resulted in a low recurrence rate of 9% over a mean follow-up of 22 months.
- Subconjunctival clindamycin demonstrated good tolerance, with rare serious side effects.
- Clindamycin offers a potentially safer and effective alternative to standard TRC treatments.
Implications:
- Subconjunctival clindamycin with oral corticosteroids may be a viable alternative to pyrimethamine-sulfadiazine or pyrimethamine-azithromycin for TRC.
- Further controlled studies are warranted to confirm the efficacy and safety of this treatment approach.
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