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A pathogenic role for secretory IgA in IgA nephropathy

B D Oortwijn1, P J M van der Boog, A Roos

  • 1Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

Kidney International
|January 6, 2006
PubMed
Summary

Secretory IgA (SIgA) binds strongly to human mesangial cells and accumulates in IgA nephropathy (IgAN) glomeruli. These findings suggest a significant role for SIgA in IgAN pathogenesis.

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