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Published on: July 6, 2016
Synthesis and characterization of water-soluble two-photon excited blue fluorescent chromophores for bioimaging
Ali Hayek1, Frédéric Bolze, Jean-François Nicoud
1Groupe des Matériaux Organiques, Institut de Physique et Chimie des Matériaux de Strasbourg, CNRS, 23 rue du Loess, F-67034, Strasbourg, France.
Abstract:
We report here the synthesis and characterization of a new type of non-ionic blue fluorescent water-soluble chromophores specifically designed for two-photon absorption microscopy. The water solubility is induced by introduction of short oligo(ethylene glycol) monomethyl ether moieties. This work has led to low molecular weight dyes with efficient two-photon absorption cross sections and high fluorescence quantum yield in organic solvents as well as in aqueous solutions.
