Related Experiment Video
Updated: Aug 13, 2026
![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Template synthesis of 9-membered triphospha-macrocycles with rigid o-phenylene backbone functions
Peter G Edwards1, Mark L Whatton
1School of Chemistry, Cardiff University, Cardiff, UKCF10 3AT. edwardspg@cardiff.ac.uk
Abstract:
[eta(5)-Cp(R)Fe(CH3CN)(1,2-diphosphinobenzene)]+ complexes are readily formed from [eta(5)-Cp(R)FeL3]+ salts and act as template precursors for the intramolecular hydrophosphination of co-ordinated trivinylphosphine with 1,2-diphosphinobenzenes. This sequence constitutes a versatile synthetic route to a new class of co-ordinated triphosphacyclononanes bearing a rigid o-phenylene backbone link. The efficiency of the synthesis depends markedly upon the nature of the Cp(R) ligand. The new secondary phosphine macrocycles prepared by this route are readily alkylated to tritertiary triphosphine macrocycles bearing alkyl and pendant functions.
Related Concept Videos
Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)
ATP and Macromolecule Synthesis
Most macromolecules are composed of single subunits, or building blocks, called monomers. The monomers combine with each other using covalent bonds to form larger molecules known as polymers.
Conversion of...
Aromatic Hydrocarbon Cations: Structural Overview
Removing one hydrogen from the intervening CH2 group with both...
Five-Membered Heterocyclic Aromatic Compounds: Overview
Structure and Nomenclature of Epoxides
Woodward–Hoffmann Selection Rules and Microscopic Reversibility

