Related Experiment Video
Updated: Jul 16, 2026

Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome
Published on: March 4, 2016
Linking age-related changes in skeletal muscle mass and composition with metabolism and disease
1Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
Abstract:
Skeletal muscle (SM) plays a central role in many biological functions, such as movement and metabolism, and alterations in SM mass and composition can have a marked influence on health and disease. The purpose of this review was to examine and characterize age-related changes in SM mass and composition and to link these changes to corresponding changes in metabolism and disease. It can be concluded from several studies that SM mass decreases with advancing age in both men and women. The age-related reduction in SM, also known as sarcopenia, is related to a corresponding reduction in SM strength, and if left untreated, sarcopenia may lead to functional impairment and physical disability. An emerging body of evidence also suggests that age-related changes in the composition of SM, particularly the accumulation of lipids within SM fibers, may lead to metabolic disorders such as insulin resistance.
More Related Videos
09:40Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
Published on: January 19, 2017
08:12Measurement of Mitochondrial Respiration in Human and Mouse Skeletal Muscle Fibers by High-Resolution Respirometry
Published on: October 4, 2024
Related Concept Videos
Cross-bridge Cycle
The Effect of Aging on Tissues
The Functions of the Skeletal System
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Disorders of the Skeletal Muscle
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...