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Updated: Aug 13, 2026

Characteristics of Precipitation-formed Polyethylene Glycol Microgels Are Controlled by Molecular Weight of Reactants
Published on: December 23, 2013
A thermodynamic study of retention of poly(ethylene glycol)s in liquid adsorption chromatography on reversed phases
Bernd Trathnigg1, Martin Veronik
1Institute of Chemistry, Karl-Franzens-University, Heinrichstrasse 28, A-8010 Graz, Austria. trathnig@kfunigraz.ac.at
Abstract:
The retention behaviour of poly(ethylene glycol)s (PEGs) on various reversed phase columns has been studied in liquid interaction chromatography at different temperatures. Similar separations could be achieved in different mobile phases. In methanol-water practically no temperature dependence was observed, while in acetone-water retention decreased with increasing temperature. From the van't Hoff plots the thermodynamic parameters were calculated, which showed, that retention is driven by enthalpy in methanol-water, while in acetone-water the driving force is entropy.
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